Item Power Set: Eye of Agamotto (MCU)
Thanos told Doctor Strange it would be “mercy” to kill half of all life in the universe in an instant, but with planets separated by billions of light years that isn’t possible without the Time Stone. The Mad Titan can freeze time everywhere, regardless of relativity, so all of those deaths happened at the same exact moment.
This might seem like the most obvious use of any individual stone, but we know from the end of Doctor Strange that using the Time Stone on such a grand scale runs “contrary to the natural order of things,” which is why it is probably the only Infinity Stone that needed another one to counterbalance it, using the Reality Stone.
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Marvel Plot Points 